PP195 Cost Utility Of Transcatheter Aortic Valve Implantation For Patients With Inoperable Severe Aortic Stenosis In Brazil

Introduction Transcatheter aortic valve implantation (TAVI) represents a new treatment option for stenosis. This study aimed to evaluate the cost utility of TAVI, compared with clinical treatment, in patients inoperable severe stenosis from perspective Brazilian public health system. Methods A Markov model monthly cycles and five percent annual discount rate was constructed. five-year time horizon chosen, minimize uncertainties inherent data extrapolations, based on only randomized head-to-head trial, Placement AoRTic TraNscathetER Valve Trial (PARTNER B). All costs were obtained Brazil's official healthcare data. Utilities 0.6 (range 0.56–0.63) TAVI 0.71 0.69–0.72) studies that used EuroQol-5D instrument. TAVI's measures penalized by 25 first month, estimate procedure's impact quality life provided National Institute Health Care Excellence United Kingdom. Lastly, deterministic probabilistic sensitivity analyses robustness results. Results The incremental cost-effectiveness ratio USD35,880 per quality-adjusted life-year (QALY), result mainly sensitive univariate analysis. In analysis, all values above reference willingness-to-pay threshold three times capita gross domestic product (USD18,042 QALY). Conclusions conclusion, even though there is no established Brazil, may represent an obstacle its incorporation into